Many simulation models involve inputs and parameters, which are not precisely known. Global sensitivity analysis aims to identify these inputs and parameters whose uncertainty has the largest impact on the variability of model output. In this paper, an efficient global sensitivity analysis method based on sequential
Latin hypercube sampling is proposed. Firstly, the basic theory of Sobol’ method is formulized and a generalized estimator of first order sensitivity analysis indices is proposed. Then, a sequential sampling strategy based on extended optimal Latin hypercube sampling is adopted to improve the sampling efficiency of sensitivity analysis. Finally, the proposed method is verified by the test function.