There is a large variety of data-centered therapy support systems involving self-management for medical purposes, usually referred to as Mobile Patient Monitoring Systems (MPMS). The considerable growth of MPMS and the variety of options afforded by the mobile sensors of smart instruments lead to enormous development cost. The range of options is commonly explored in trial and error, incurring significant expenditures of time and funds. This paper presents a simulation framework that offers a capability to run these trials in a simulation-based fashion and thereby achieve quicker and more cost-effective results than was previously possible.