The changing practice of healthcare, particularly the increasing use of applications of artificial intelligence (AI), requires significant reforms in educating healthcare professionals. Without reform, practitioners will underperform and fail to realize the potential of personalized care. There have been many reports about needed reforms that have common themes: including expanded emphasis on communication, teamwork, riskmanagement, and patient safety. These reforms are essential, but insufficient. Most of the proposals do not address the most fundamental challenge—the fact that the practice of medicine is rapidly transitioning from one based on information to one based on artificial intelligence. What most employers need are healthcare professionals who are able to work at the top of their license, possess knowledge spanning the various health professions and the care continuum, effectively leverage data platforms, focus on analyzing outcomes and improving performance, and communicate the meaning of the probabilities generated by big data to patients.