Electrochemotherapy (ECT) is a combined treatment that exploits the administration of chemotherapeutic drugs and cell membrane reversible electroporation. ECT increases elective drug penetration into cytoplasma of treated tissues and allows a tissue sparing treatment. This article describes a single center experience of ECT for the treatment of unresectable cutaneous and subcutaneous tumors. Safety, tolerability and correlation between tumor’s characteristics and clinical response were the question of research. On the basis of the study, other important application should start.