Under the Industry 4.0 framework, a plethora of digital technologies and techniques has been introduced in the Manufacturing domain. Machine tools must become more intelligent, in order to create a network of fully connected
machines. By extension, this will lead to the creation of the Industrial Internet of Things (IIoT). Although these technologies provide for increased functionality of the manufacturing equipment, there are certain issues/implications,
refraining engineers from integrating such technologies in the production. Therefore, in this paper, the results of a systematic literature review are presented and discussed, including the horizontal and vertical integration
of such digital technologies. The contribution of this paper extends to the recognition of the opportunities emerging as well as the identified implications from a practical implementation point of view.