Iron & Steel facilities are characterized by presence of multiple risks caused by the nature of industrial processes. For this reason, the use of innovative solutions in order to support the work of operators and replace them during most dangerous tasks is growing more and more. In this study the authors propose the utilization of autonomous systems to cover some of the most critical and statistically dangerous routine tasks. In particular, we analyzed the utilization of modeling and simulation (M&S) and digital twin approaches in order to support the development of new autonomous vehicles as well as new procedures. Example of a virtual prototype in a 3D environment is provided.