With the outbreak of a pandemic due to the SARS-CoV-2 virus, the present paper gives an overview of the impacts that this unprecedented situation has had on the environment, the economy and society so far. It will be explained in the paper in what way modeling and simulation helps to understand and to forecast the spread of disease by focusing on compartment models and agent-based models. The presentation of the extent of the consequences in the form of a literature review and the following derivation of recommendations for action highlight the weaknesses of the current economic system. In this respect, the key finding of the research showed that society would be more resilient towards crises like COVID-19 with a regionally and long-term oriented economy that puts social equity and environmental protection first. Therefore, political leaders must rethink the way business is done and should use the crisis as an opportunity to unite the rebuilding of the economy with sustainable development. Models and simulations can assist in finding an appropriate action plan.