The paper addresses the development of an innovative solution based on Autonomous Systems to operated within Industrial Plants based on the advance of technologies in this sector and investing new operational frameworks. Indeed the authors propose the adoption of digital twin approach in order to support the design of this new solution as well as on the development of new procedures and policies applied to iron & steel facilities. A real-life case study with relative system architecture and common control of the real and virtual replica is analyzed. Synthetic description of obtained results is presented.